Abbreviated title: NMDA receptor-mediated enhancement at GABAergic synapses
نویسندگان
چکیده
NMDA receptor activation enhances inhibitory GABAergic transmission onto 1 hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms 2 3 Jiu-Gang Xue, Takayoshi Masuoka, Xian-Di Gong, Ken-Shiung Chen, 4 Yuchio Yanagawa, S.K. Alex Law, and Shiro Konishi 5 6 Department of Neurophysiology, Kagawa School of Pharmaceutical Sciences and 7 Institute of Neuroscience, Tokushima Bunri University, Kagawa 769-2193, Japan; 8 School of Biological Sciences, Nanyang Technological University, 637551 9 Singapore; Institute of Microelectronics, A-STAR, 117685 Singapore; and 10 Department of Genetic and Behavioral Neuroscience, Gunma University Graduate 11 School of Medicine, Maebashi 371-8511, Japan 12 13 Abbreviated title: NMDA receptor-mediated enhancement at GABAergic synapses 14 15 *Correspondence should be addressed to: 16 Dr. Shiro Konishi 17 Department of Neurophysiology Kagawa School of Pharmaceutical Sciences 18 & Institute of Neuroscience, Tokushima Bunri University. 19 1314-1 Shido, Sanuki-shi, Kagawa 769-2193, Japan. 20 Phone: +81-87-894-5111, Fax: +81-87-894-0181 21 E-mail: [email protected] 22 23 Articles in PresS. J Neurophysiol (April 6, 2011). doi:10.1152/jn.00287.2010
منابع مشابه
NMDA Receptors in GABAergic Synapses during Postnatal Development
GABA (gamma-aminobutyric-acid), the main inhibitory neurotransmitter in the adult brain, exerts depolarizing (excitatory) actions during development and this GABAergic depolarization cooperates with NMDARs (N-methyl-D-aspartate receptors) to drive spontaneous synchronous activity (SSA) that is fundamentally important for developing neuronal networks. Although GABAergic depolarization is known t...
متن کاملNMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms.
N-methyl-D-aspartate (NMDA) receptors (NMDARs) are implicated in synaptic plasticity and modulation of glutamatergic excitatory transmission. Effect of NMDAR activation on inhibitory GABAergic transmission remains largely unknown. Here, we report that a brief application of NMDA could induce two distinct actions in CA1 pyramidal neurons in mouse hippocampal slices: 1) an inward current attribut...
متن کاملDepolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo.
Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear. We investigated the role of GABAA receptor-mediated Cl- conductances in the development of synaptic responses in the Xenopus visual system. Intracellular Cl- concentration ([Cl-]i) was found to be high in immature tectal neurons and then f...
متن کاملNMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling.
GABAergic inhibition plays a central role in the control of pyramidal cell ensemble activities; thus, any signaling mechanism that regulates inhibition is able to fine-tune network patterns. Here, we provide evidence that the retrograde nitric oxide (NO)-cGMP cascade triggered by NMDA receptor (NMDAR) activation plays a role in the control of hippocampal GABAergic transmission in mice. GABAergi...
متن کاملMechanisms of induction and expression of long-term depression at GABAergic synapses in the neonatal rat hippocampus.
Synaptic plasticity at excitatory glutamatergic synapses is believed to be instrumental in the maturation of neuronal networks. Using whole-cell patch-clamp recordings, we have studied the mechanisms of induction and expression of long-term depression at excitatory GABAergic synapses in the neonatal rat hippocampus (LTD(GABA-A)). We report that the induction of LTD(GABA-A) requires a GABA(A) re...
متن کامل